Rebuilding OST - Any Concerns?

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Britonius

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Outlook version
Outlook 2010 64 bit
Email Account
Exchange Server
Microsoft seems to recommend simply deleting and letting Outlook 2010 rebuild the OST file upon restart, if there are any issues with the file or profile per http://support.microsoft.com/kb/983036. I have used scanpst.exe, but as they mention it can take quite some time. Are there any concerns with losing settings or settings being reset by rebuilding the OST file? Or any other concerns?
 
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