In the reading pane: you have limited options - go to tools, options, mail format: try changing the CSS font formatting option then go to stationery and fonts to set the font for plain text. Generally speaking you can't change the font for HTML but can zoom - hold Ctrl as you roll the mouse wheel. It doesn't stick though.
To change the font in the message list, look on the View menu for Define views then select the view you are using (usually Messages). Modifiy it - changing either the Row font under Other settings or the Automatic formatting for read and unread.
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