Outlook clients did not reconnect to Exchange when one CAS server in CAS array became unresponsive

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Outlook version
Outlook 2013 64 bit
Email Account
Exchange Server 2010
Hello All

We have a CAS array with two CAS servers in the array and a Netscaler load balancer. One of the CAS servers became unresponsive for a few minutes but some outlook clients were not able to reconnect to outlook even though second CAS server was still functional. What are the possible reasons?

Thank you in advance for your input!
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