Outlook 365 I am getting the "Either there is no default mail client" error when I try to send an email on excel Office 365

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Outlook version
Outlook 365 32 bit
Email Account
I am getting the "General Mail failure" error when I try to send an attachment e-mail through Excel.

I installed another mail client and it works when I use the other mail client.

I tried the following:

- Ensured Outlook was set as the default mail client

- Did a Quick Repair

- Disabled Cortana

- Uninstalled the 64-bit version and installed the 32-bit version

- I used the Microsoft Support Assistant tool to completely remove Office 365 and reinstalled it

- I used CCleaner to clean up the registry

- I tried to edit the following Registry: Computer\HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Windows Messaging Subsystem\MSMapiApps

According to the solution, there should be a Version REG_SZ file and I should rename it to Version_Renamed. I can't find the file under the subkey MSMapiApps

- The other solution is to delete the MAPI file under Program Files Common Files, but there is no file to delete it


  • 5f6dd948-c01b-4bcb-bfda-c651f09df3ab_AddIns.txt
    2.2 KB · Views: 0
  • SearchProtocolHost_7_0_19041_2546-20230222T1124270192-18896-HR.txt
    906 bytes · Views: 0
  • SearchProtocolHost_7_0_19041_2546-20230221T1610490670-8960-HR.txt
    903 bytes · Views: 0
  • OUTLOOK_16_0_15601_20538-20230222T1124250259-10836-HR.txt
    623.4 KB · Views: 0
  • OUTLOOK_16_0_15601_20538-20230221T1610480133-6796-HR.txt
    299.9 KB · Views: 0
  • EXCEL_16_0_15601_20538-20230222T1124410997-19316-HR.txt
    5.7 KB · Views: 0
  • EXCEL_16_0_15601_20538-20230221T1612440776-7256-HR.txt
    877 bytes · Views: 0
  • d29fd3e3-6a10-4c2b-ade2-5e5f6a16bab5_AddIns.txt
    2.2 KB · Views: 0
  • 2088c4d0-09f7-4d98-9b7c-c4c7b31ecbc1_OutlookProfile.txt
    65 KB · Views: 0
  • 09eb4ea1-7992-4c76-a648-f08b54faf862_OutlookProfile.txt
    65 KB · Views: 0
This is what I have in that key - actually in both keys -
  • HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows Messaging Subsystem\MSMapiApps
  • HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Microsoft\Windows Messaging Subsystem\MSMapiApps


NOTE: If you do not find the Version value with no data associated with it, or the Version value does not exist at all under this registry path, then there is a different cause of the error. Please search the Microsoft Knowledge Base for additional causes of this error.

What do you have in these keys:

If that doesn’t exist, it will fall back to HKLM;
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